Sigma-Aldrich CompoZr ZFN Ad

Published on Nov 13, 2015

CompoZr® Zinc Finger Nucleases are a class of engineered DNA-binding proteins that facilitate genome editing by creating a double-stranded break in DNA at a user-specified location. A double-stranded break is important for site-specific mutagenesis in that it stimulates the cell’s natural DNA-repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ). Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted in vivo genomic edits with targeted gene deletions (Knockouts). Here, Professor Peter Currie (Monash University, Australia) speaks about the application of this technology in studying neuromuscular disease

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