Sangamo's Press Release Today

RICHMOND, Calif., Sept. 21, 2015 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) presented data demonstrating sustained functional control of viral load in the absence of antiretroviral drugs (ART) in two of three HIV-infected subjects treated in Cohort 3* of its Phase 1/2 study (SB-728-1101) of its ZFP Therapeutic (SB-728-T) for the treatment of HIV/AIDS.  The subjects remain on extended treatment interruption (TI), past the initial 16 week TI period. The data, which led to expanded enrollment of this Cohort, were presented at the 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy (ICAAC) in San Diego September 17-21
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The ability of subjects treated in Cohort 3* to suppress and sustain control of viral load, combined with durable increases in CD4 and CD8 cells, provide support for our hypothesis of an immunologic mechanism of action for SB-728," said Dale Ando, M.D., Sangamo's vice president of therapeutic development and chief medical officer. "The prolonged positive effects observed in these Cohort 3* subjects have not been seen before with other treatments and have encouraged us to enroll and treat additional five subjects with this regimen."