A recent study from Australia has shown that it takes from 5 to 7 days for HIV to activate from latency following a treatment interruption. They also estimate that viral replication begins on average every six days or so, approximately 24 times more slowly than previously thought. The data also suggests that a single cell becomes actively infected around once a week when an individual is on HAART. Prior studies predicted this occurred several times a day. According to the authors calculations reducing the reservoir by 50 to 70 fold instead of SEVERAL THOUSAND FOLD, might be enough to allow for prolonged treatment interruption.
Now for the Sangamo data:
From Sangamo ICAAC Press Release dated September 8th, 2014
" A median 0.9 log decrease in the size of the HIV reservoir at 36 months was observed in nine of nine subjects treated, as demonstrated by measurement of HIV total DNA in PBMCs." "The data demonstrate that SB-728-T treatment is associated with reduction in both the VL and the levels of the reservoir."
Looks like they are on the right track.
The Australian Study:
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005000
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