Sangamo Files Patent Application for TCR Cell Editing

Here is the info from Freepatentsonline.com:
The present application is a continuation of U.S. patent application Ser. No. 12/927,292, filed Nov. 10, 2010

Title: TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES Document Type and Number: United States Patent Application 20150164954 Kind Code: A1 Abstract: Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided. Bonini, Maria Chiara (Milan, IT)  Genovese, Pietro (Milan, IT)  Gregory, Philip D. (Richmond, CA, US)  Holmes, Michael C. (Richmond, CA, US)  Naldini, Luigi (Milan, IT)  Paschon, David (Richmond, CA, US)  Provasi, Elena (Milan, IT)  Zhang, Lei (Richmond, CA, US)  Application Number: 14/591625 Publication Date: 06/18/2015 Filing Date: 01/07/2015 View Patent Images: Download PDF 20150164954         PDF help Export Citation: Click for automatic bibliography generation International Classes: A61K35/28; C07K14/725; A61K35/17; C12N15/01