Philip D. Gregory, D. Phil. , Chief Scientific Officer and Senior Vice President, Research of Sangamo BioSciences (SGMO) is presenting at mSBW2.0. This is the International Workshop on Mamilian Synthetic Biology 2.0 Recognizing the fast emergence and potential significance of this field, the aim of this workshop series is to bring practitioners of mammalian synthetic biology together with experts from other relevant fields. The general goals of the workshop are to nucleate the nascent mammalian synthetic biology community, reach out to experts from other fields that can benefit from and contribute to this field, and define the important challenges and future directions. The workshop provides a forum for exposition of the latest developments in the field and discussions of how experts from other fields can benefit from and contribute to mammalian synthetic biology.
Agenda
| Saturday April 25, 2015 | |
| 8:00 | Registration |
| 8:15 | Welcome and Introduction |
| | Ron Weiss, MIT |
| 8:30 | Keynote Speaker |
| | Professor Elaine Fuchs, The Rockefeller University: "Skin Stem Cells and Their Cancers" |
| 9:30 – 10:30 | Session 1 - Foundational Technologies |
| | George Church, Harvard University: "Engineering mammalian genetic systems, neuro-systems and ecosystems" |
| | Remus Wong, Stanford University: RNA Regulation of Expression |
| 10:30 – 10:45 | Break |
| 10:45 – 12:15 | Session 2 - Directing Cell Phenotype |
| | Charles Gersbach, Duke University: "Epigenome Engineering to Control Cell Phenotype" |
| | Wendell Lim, UCSF: "Redesigning the T Cell" |
| | Wilson Wong, Boston University: "Robust and scalable biocomputers in mammalian cells" (short talk) |
| | Michael Todhunter, UCSF: "Rapid Synthesis of 3D Tissues by Chemically Programmed Assembly" (short talk) |
| 12:15 – 1:30 | Lunch |
| 1:30 – 3:00 | Session 3 - Design and Optimization of Genetic Circuits |
| | Michael Elowitz, Caltech: "Design principles for signaling and memory circuits" |
| | Leonidas Bleris, University of Texas, Dallas: "Custom architectures for control in mammalian cells" |
| | Silvana Konermann, MIT: "An engineered CRISPR/Cas9 complex for genome-scale transcriptional activation" (short talk) |
| | Tasuku Kitada, MIT: "RNA encoded circuits with small molecular based regulation for 'smart vaccination'" (short talk) |
| 3:00 – 3:15 | Break |
| 3:15 – 4:45 | Session 4 - Functions of Multicellular Systems |
| | Ed Boyden, MIT: "Tools for Mapping and Controlling Complex Biological Systems" |
| | Geraldine Hamilton, Emulate: "Organs-on-Chips: A unique window into human biology and disease" |
| | Jonathan Brunger, Duke University: "Targeted genome engineering of iPSCs to produce auto-regulated inflammation resistance for regenerative medicine" (short talk) |
| | Daniel Woodsworth, Genome Sciences Centre: "A lymphocyte based cell-to-cell therapeutic delivery system" (short talk) |
| 4:45 – 5:00 | Break |
| 5:00 – 6:00 | Session 5 - Gene Regulation and Epigenetic Control |
| | Karmella Haynes, Arizona State University: "Regulating human cancer epigenomes with synthetic chromatin" |
| | Kobi Benenson, ETH: "Biological Computing Meets Synthetic Biology" |
| 6:00 - 8:00 | Poster Session and Reception |
| | |
| Sunday, April 26, 2015 | |
| 8:00 – 8:30 | Breakfast |
| 8:30-9:30 | Closing Plenary |
| | Professor David Baltimore, California Institute of Technology: "Engineering the Immune System" |
| 9:30-10:30 | Session 1 - Circuits and Pathways |
| | Joshua Leonard, Northwestern University: "Engineering Cell-based Devices that Interface Robustly with Host Physiology" |
| | Timothy Lu, MIT: "Massively Parallel Combinatorial Genetics" |
| 10:30-10:45 | Break |
| 10:45-12:00 | Session 2: Industry Research |
| | Sean Stevens, Synthetic Genomics, Inc.: "Synthetic Biology and Cell Engineering for Biomedical Use" |
| | Jon Chesnut, Thermo Fisher Scientific: "Democratizing cell engineering: New tools for simplifying and shortening the genome editing workflow" |
| | Jose-Carlos Gutierrez-Ramos, Pfizer BioTherapeutics |
| | Philip Gregory, Sangamo Biosciences: "Therapeutic Genome Editing - An Industry Perspective" |
| | Emily Leproust, Twist Biosciences |
| 12:00-1:00 | Lunch |
| 1:00-2:30 | Session 3 - Towards cell-based therapies |
| | Michel Sadelain, Memorial Sloan Kettering Cancer Center: "CAR therapy and the promise of T cell engineering" |
| | Yvonne Chen, University of California: "Engineering Smarter and Stronger T Cells for Cancer Therapy" |
| | |
| 2:30-2:45 | Closing Remarks |
| | Ron Weiss, MIT |
| 2:45 | Adjourn |
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